Dose Additivity Guidance
ثبت نشده
چکیده
منابع مشابه
Parallel dose-response curves in combination experiments.
A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...
متن کاملDefining an additivity framework for mixture research in inducible whole-cell biosensors
A novel additivity framework for mixture effect modelling in the context of whole cell inducible biosensors has been mathematically developed and implemented in R. The proposed method is a multivariate extension of the effective dose (EDp) concept. Specifically, the extension accounts for differential maximal effects among analytes and response inhibition beyond the maximum permissive concentra...
متن کاملNeurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design.
Environmental exposures generally involve chemical mixtures instead of single chemicals. Statistical models such as the fixed-ratio ray design, wherein the mixing ratio (proportions) of the chemicals is fixed across increasing mixture doses, allows for the detection and characterization of interactions among the chemicals. In this study, we tested for interaction(s) in a mixture of five organop...
متن کاملA unifying concept for assessing toxicological interactions: changes in slope.
Robust statistical methods are important to the evaluation of toxicological interactions (i.e., departures from additivity) among chemicals in a mixture. However, different concepts of joint toxic action as applied to the statistical analysis of chemical mixture toxicology data or as used in environmental risk assessment often appear to conflict with one another. A unifying approach for applica...
متن کاملAppendix a Background Information on the Assessment of Additivity and Interactions
The approaches to assessing the joint action of components of a mixture are based in large measure on the conceptual groundwork laid by Bliss (1939) and Finney (1971), and are mathematical rather than biological in nature. The approaches commonly known as dose addition and response addition, discussed in the following sections, are non-interactive forms of joint action that assume the chemicals...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016